Research Papers – Peer Reviewed

1. Zhu Q, Kao L, Azimov R, Newman D, Liu W, Pushkin A, Abuladze N, Kurtz I. Topological Location and Structural Importance of the NBCe1-A Residues Mutated in Proximal Renal Tubular Acidosis. J Biol. Chem. 285(18):13416-26, 2010. 

2. Lacruz RS, Hilvo M, Kurtz I, Paine ML. A Survey of Carbonic Anhydrase mRNA Expression in Enamel Cells. Biochem Biophs Res. Commun. 393(4):883-7, 2010.

3. Lacruz RS, Nanci A, White SN, Wen X, Wang H, Zalzal SF, Luong VQ, Schuetter VL, Conti PS, Kurtz I, Paine ML. The Sodium Bicarbonate Cotransporter (NBCe1) is Essential for the Normal Development of Mouse Dentition. J Biol. Chem., 285(32):24432-8, 2010.

4. Tsirulnikov K, Abuladze N, Koag MC, Newman D, Scholz K, Bondar G, Zhu Q, Avliyakulov NK, Dekant W, Faull K, Kurtz I, Pushkin A. Transport of N-Acetyl-S-(1,2-Dichlorovinyl)-L-Cysteine, a Metabolite of Trichloroethylene, by  Mouse Multidrug Resistance Associated Protein 2 (Mrp2). Toxicol. Appl. Pharmacol. 244(2):218-25, 2010.

5. Hsieh JM, Tsirulnikov K, Sawaya MR, Magilnick N, Abuladze N, Kurtz I, Abramson J,   Pushkin A. Structures of Aminoacylase 3 In Complex With Acetylated Substrates. Proc. Natl. Acad. Sci. U S A. 107(42):17962-7, 2010.

6. Zhu Q, Kao L, Azimov R, Abuladze N, Newman D, Pushkin A, Liu W, Chang C, Kurtz I. Structural and Functional Characterization of the C-Terminal Transmembrane Region of NBCe1-A. J. Biol. Chem. 285(48):37178-87, 2010.

7. Nguyen MK, Kao L, Kurtz I. Defining the Buffering Process by a Triprotic Acid Without Relying on Stewart-Electroneutrality Considerations. Theor. Biol. Med. Model. 8:29, 1-11, 2011.

8. Kao L, Kurtz LM, Shao X, Papadopoulos MC, Liu L, Bok D, Nusinowitz S, Chen B, Stella SL, Andre M, Weinreb J, Luong SS, Piri N, Kwong JM, Newman D, Kurtz I. Severe Neurologic Impairment In Mice With Targeted Disruption of the Electrogenic Sodium Bicarbonate Cotransporter NBCe2 (Slc4a5 Gene). J. Biol.Chem. 286(37):32563-74, 2011.

9. Snead CM, Smith SM, Sadeghein N, Lacruz RS, Hu P, Kurtz I, Paine ML. Identification of a pH-Responsive DNA Region Upstream of the Transcription Start Site of Human NBCe1-B. Eur. J. Oral Sci. 119 Suppl 1:136-41, 2011.

10. Lacruz RS, Smith CE, Bringas Jr. P, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML. Identification of Novel Candidate Genes Involved In Mineralization of Dental Enamel by Genome-Wide Transcript Profiling. J. Cell Physiol. 227(5):2264-75, 2012.

11. Burette AC, Weinberg RJ, Sassani P, Abuladze N, Kao L, Kurtz I. The Sodium-Driven Chloride/Bicarbonate Exchanger In Presynaptic Terminals. J. Comp. Neurol. 520(7):1481-92, 2012.

12. Lacruz RS, Smith CE, Moffatt P, Chang EH, Bromage TG, Bringas P Jr, Nanci A, Baniwal SK, Zabner J, Welsh MJ, Kurtz I, Paine ML. Requirements for Ion and Solute Transport, and pH Regulation During Enamel Maturation. J. Cell Physiol. 227(4):1776-85, 2012.

13. Sergeev M, Godin AG, Kao L, Abuladze N, Wiseman PW, Kurtz I. Determination of Membrane Protein Transporter Oligomerization In Native Tissue Using Spatial Fluorescence Intensity Fluctuation Analysis. PLoS One. 7(4):e36215, 2012. 

14. Kao L, Abuladze N, Shao XM, McKeegan K, Kurtz I. A New Technique for Multiple Re-Use of Planar Patch Clamp Chips. J. Neurosci. Methods. 208(2):205-10, 2012.

15. Kurtz L, Kao L, Newman D, Kurtz I, Zhu Q. Integrin αIIbβ3 Inside-Out Activation: An In Situ Conformational Analysis Reveals a New Mechanism. J. Biol. Chem. 287(27):23255-65, 2012 . 

16. Hu P, Lacruz RS, Smith CE, Smith SM, Kurtz I, Paine ML. Expression of the Sodium/Calcium/Potassium Exchanger, NCKX4, In Ameloblasts. Cells Tissues Organs.  196(6):501-9, 2012.

17. Tsirulnikov K, Abuladze N, Vahi R, Hasnain H, Phillips M, Ryan CM, Atanasov I, Faull KF, Kurtz I, Pushkin A. Aminoacylase 3 Binds to and Cleaves the N-Terminus of the Hepatitis C Virus Core Protein. FEBS Lett. 586(21):3799-804, 2012.

18. Lacruz RS, Smith CE, Kurtz I, Hubbard MJ, Paine ML. New Paradigms on the Transport Functions of Maturation-Stage Ameloblasts. J. Dent. Res. 92(2):122-9, 2013. 

19. Jiang J, Magilnick N, Tsirulnikov K, Abuladze N, Atanasov I, Ge P, Narla M, Pushkin A, Zhou ZH, Kurtz I. Single Particle Electron Microscopy Analysis of the Bovine Anion Exchanger 1 Reveals a Flexible Linker Connecting the Cytoplasmic and Membrane Domains. PLoS One. 8(2):e55408, 2013.

20. Zhu Q, Liu W, Kao L, Azimov R, Newman D, Abuladze N, Kurtz I. Topology of NBCe1 Transmembrane Segment 1 and Structural Effect of pRTA S427L Mutation. J. Biol. Chem. 288(11):7894-906, 2013.

21. Zhu Q, Shao XM, Kao L, Azimov R, Weinstein AM, Newman D, Liu W, Kurtz I. Missense Mutation T485S Alters NBCe1-A Electrogenicity Causing Proximal Renal Tubular Acidosis. Am J Physiol Cell Physiol. 305(4):C392-405, 2013. 

22. Nguyen MK, Ornekian V, Kao L, Butch AW, Kurtz I. Defining the Role of Albumin Infusion in Cirrhosis-Associated Hyponatremia. Am J Physiol Gastrointest Liver Physiol. 307(2):G229-32, 2014.

23. Wen X, Kurtz I, Paine ML. Prevention of the Disrupted Enamel Phenotype In slc4a4-Null Mice Using Explant Organ Culture Maintained In a Living Host Kidney Capsule. PLoS One. 9(5):e97318, 2014.

24. Shao XM, Kao L, Kurtz I. A Novel Delta Current Method for Transport Stoichiometry Estimation. BMC Biophys. 7(1):14, 2014.

25. Kao L, Azimov R, Abuladze N, Newman D, Kurtz I. Human SLC4A11-C Functions As a DIDS-Stimulatable H+(OH-) Permeation Pathway: Partial Correction of R109H Mutant Transport. Am J Physiol Cell Physiol, 308(2):C176-88, 2015.

26. Shcheynikov N, Son A, Hong JH, Yamazaki O, Ohana E, Kurtz I, Shin DM, Muallem S. Intracellular Cl- As a Signaling Ion That Potently Regulates Na+/HCO3- Transporters. Proc Natl Acad Sci U S A. 112(3):E329-37, 2015.

27. Zhu Q, Kao L, Azimov R, Abuladze N, Newman D, Kurtz I. Interplay Between Disulfide Bonding and N-Glycosylation Defines SLC4 Na+-Coupled Transporter Extracellular Topography. J Biol Chem. 290(9):5391-404, 2015.

28. Yin K, Lei Y, Wen X, Lacruz RS, Soleimani M, Kurtz I, Snead ML, White SN, Paine ML. SLC26A Gene Family Participate In pH Regulation During Enamel Maturation. PLoS One. 10(12):e0144703, 2015.

29. Kao L, Azimov R, Shao XM, Frausto RF, Abuladze N, Newman D, Aldave AJ, Kurtz I. Multifunctional Ion Transport Properties of Human SLC4A11: Comparison of the SLC4A11-B and SLC4A11-C Variants. Am J Physiol Cell Physiol.311(5):C820-C830, 2016.

30. Pushkin A, Mund R, Pushkin AN, Zevelev A, Newman D, Berina O, Golchin M, Kurtz I. Potassium Removal From Juices Using an Individual Single-Use Ion-Exchange Device. Journal of Food and Nutrition Sciences. 5(2): 28-33, 2017.

31. Nguyen MK, Rodriguez Gama A, Moreno E, Borschewski A, Nilson T, Proctor G, Kurtz I, et al. A Gain of Function NKCC2 Mutation In a Patient With Chronic Cyclic Edema. WebmedCentral Nephrology 8(9):wmc005325, 2017.

32. Tsirulnikov K, Duarte S, Ray A, Datta N, Zarrinpar A, Hwang L, Faull K, Pushkin A, Kurtz I. Aminoacylase 3 Is a New Potential Marker and Therapeutic Target In Hepatocellular Carcinoma. J Cancer. 9(1):1-12, 2018.

33. Huynh KW, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, Newman D, Azimov R, Pushkin A, Zhou ZH, Kurtz I. CryoEM Structure of the Human SLC4A4 Sodium-Coupled Acid-Base Transporter NBCe1. Nat Commun. 9(1):900, 2018.

34. Lang JM, Pan C, Cantor RM, Tang WHW, Garcia-Garcia JC, Kurtz I, Hazen SL, Bergeron N, Krauss RM, Lusis AJ. Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome. MBio. 9(6). pii: e01604-18, 2018.

35. Song L, Hanna RM, Nguyen MK, Kurtz I, Wilson J. A Novel Case of Pseudohyponatremia Caused By Hypercholesterolemia. Kidney Int Rep, 4(3):491-493, 2018.

36. Yang, N-Y, Mukaibo T, Kurtz I, Melvin JE.The Apical Na+-HCO3- Cotransporter Slc4a7 (NBCn1) Does Not Contribute to Bicarbonate Transport By Mouse Salivary Gland Ducts. J. Cell Physiol., 1-13, 2019.

37. Gee, MT, Kurtz I, Pannabecker TL. Expression of SLC4A11 Protein In Mouse and Rat Medulla: A Candidate Transporter Involved In Outer Medullary Ammonia Recycling. Physiological Reports. Vol 7. Issue 10, e14089, May 2019.

38. Frausto RF, Chung DD, Boere PM Swamy VS, Duong HNV, Kao L, Azimov R, Zhang W.,  Carrigan L, Wong D, Morselli M, Zakharevich M, Hanser EM, Kassels AC, Kurtz I, Pellegrini M, Aldave AJ. ZEB1 Insufficiency Causes Corneal Endothelial Cell State Transition and Altered Cellular Processing. PLoS ONE 14(6): e0218279, 2019. journal.pone.0218279

39. Hanna RM, Velez JC, Rastogi A, Nguyen M, Kamgar MK, Moe K, Arman F, Hasnain H, Nobakht N, Selamet U, Kurtz I. Equivalent Efficacy and Decreased Rate of Overcorrection In Patients With Syndrome of Inappropriate Secretion of Antidiuretic Hormone Given Very Low-Dose Tolvaptan. Kidney Med. 2(1):20-28, 2019.

40. Yang N-Y, Mukaibo T, Gao X, Kurtz I, Melvin JE. Slc4a11 Disruption Causes Duct Cell Loss and Impairs NaCl Reabsorption in Female Mouse Submandibular Glands. Physiological Reports. 7(23): E14232, 2019.

41. Zhang W, Frausto R, Chung D, Griffis CG, Kao L, Chen A, Azimov R, Sampath A, Kurtz I, Aldave A. Energy Crisis In Human and Mouse Models of SLC4A11-Associated Corneal Endothelial Dystrophies. bioRxiv. 2019. doi:

42. Kao L, Azimov R, Shao XM, Abuladze N, Newman D, Zhekova H, Noskov S, Pushkin A, Kurtz I. SLC4A11 Function: Evidence for H+(OH-) and NH3-H+ Transport. Amer J Physiol (Cell Physiol). 1:318(2):C392-C405, 2020.

43. Frausto RF, Swamy VS, Peh GSL, Boere PM, Hanser M, Chung DD, George BL, Morselli M, Kao L, Azimov R, Wu J, Pellegrini M, Kurtz I, Mehta JS, Aldave AJ. Phenotypic and Functional Characterization of Corneal Endothelial Cells During In Vitro Expansion. Scientific Reports 10:7402, 2020.

44. He C, Song W, Weston TA, Tran C, Kurtz I, Zuckerman JE, Guagliardo P, Miner JH, Ivanov SV, Bouguoure J, Hudson BG, Colon S, Voziyan PA, Bhave G, Fong LG, Young SG, Jiang H. Peroxidasin-Mediated Bromine Enrichment of Basement Membranes, PNAS, pp. 1-10,, 2020.

45. Ahn IS, Lang JM, Olson CA, Diamante G, Zhang G, Ying Z, Byun HR, Cely I, Ding J, Cohn P, Kurtz I, Gomez-Pinilla F, Lusis AJ, Hsiao EY, Yang X. Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice. Journal of Nutrition, doi:

46. Zhekova HR, Pushkin A, Kayık G, Kao L, Azimov R, Abuladze N, Kurtz D, Damergi M, Noskov S, Kurtz I. Identification of Multiple Substrate Binding Sites In SLC4 Transporters in the Outward-Facing Conformation: Insights Into the Transport Mechanism, Jour Biol Chemistry, 2021, doi:

47. Wang W, Tsirulnikov K, Zhekova HR, Kayik G, Khan HM, Azimov R, Abuladze N, Kao L, Newman D, Noskov SY, Zhou ZH, Pushkin A, Kurtz I. Cryo-EM Structure of the Sodium-Driven Chloride/Bicarbonate Exchanger NDCBE. Nature Communications, 12, Article number 5690, 2021.